Publications

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Long-acting Nanoparticulate DNase-1 for Effective Suppression of SARS-CoV-2-mediated Neutrophil Activities and Cytokine Storm

Yun Young Lee†, Hee Ho Park†, Wooram Park†, Hyelim Kim†, Jong Geol Jang, Kyung Soo Hong, Jae-Young Lee, Hee Seung Seo, Dong Hee Na, Tae-Hyung Kim, Young Bin Choy, June Hong Ahn,*, Wonhwa Lee,* and Chun Gwon Park

† These authors contributed equally to this work.

Bioinspired DNase-I-coated melanin-like nanospheres for modulation of infection-associated NETosis dysregulation

Hee Ho Park‡, Wooram Park‡, Yun Young Lee‡, Hyelim Kim, Hee Seung Seo, Dong Wook Choi, Ho-Keun Kwon, Dong Hee Na, Tae-Hyung Kim, Young Bin Choy, June Hong Ahn*, Wonhwa Lee* and Chun Gwon Park*

‡ These authors contributed equally to this work.

COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

Wonhwa Lee¹, June Hong Ahn¹, Hee Ho Park¹, Hong Nam Kim¹, Hyelim Kim, Youngbum Yoo, Hyosoo Shin, Kyung Soo Hong, Jong Geol Jang, Chun Gwon Park, Eun Young Choi*, Jong-Sup Bae* and Young-Kyo Seo*

¹ These authors contributed equally to this work.

Brimonidine–Montmorillonite Hybrid Formulation for Topical Drug Delivery to the Eye

Chun Gwon Park‡, Goeun Choi‡, Myung Hun Kim‡, Se-Na Kim, Hanna Lee, Na Kyeong Lee, Young Bin Choy* and Jin-Ho Choy*

‡ These authors contributed equally to this work.

Protein-Based Nanoparticles as Drug Delivery Systems

Seyoung Hong†, Dong Wook Choi†, Hong Nam Kim†, Chun Gwon Park*, Wonhwa Lee* and Hee Ho Park*

† These authors contributed equally to this work.

Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson’s disease rat model

Hyung Woo Park¹, Chun Gwon Park¹, Min Park¹, Seung Ho Lee, Hye Ran Park, Jaesung Lim, Sun Ha Paek* and Young Bin Choy*

¹ These authors contributed equally to this work.

Biomaterial-based strategies to prime dendritic cell-mediated anti-cancer immune responses

Wooram Park‡, Kwang Hoon Song‡, Jaesung Lim, Chun Gwon Park, Junsang Doh* and Dong Keun Han*

‡ These authors contributed equally to this work.

A fibronectin-coated gold nanostructure composite for electrochemical detection of effects of curcumin-carrying nanoliposomes on human stomach cancer cells

Novi Angeline, Intan Rosalina Suhito, Cheol-Hwi Kim, Geun-Pyo Hong, Chun Gwon Park, Suk Ho Bhang, Zhengtang Luo and Tae-Hyung Kim*

Implantable multireservoir device with stimulusresponsive membrane for on-demand and pulsatile delivery of growth hormone

Seung Ho Lee¹, Huiyan Piao¹, Yong Chan Cho, Se-Na Kim, Goeun Choi, Cho Rim Kim, Han Bi Ji, Chun Gwon Park, Cheol Lee, Chong In Shin, Won-Gun Koh, Young Bin Choy* and Jin-Ho Choy*

¹ These authors contributed equally to this work.

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

Jean Albrengues, Mario A. Shields, David Ng, Chun Gwon Park, Alexandra Ambrico, Morgan E. Poindexter, Priya Upadhyay, Dale L. Uyeminami, Arnaud Pommier, Victoria Küttner, Emilis Bružas, Laura Maiorino, Carmelita Bautista, Ellese M. Carmona, Phyllis A. Gimotty, Douglas T. Fearon, Kenneth Chang, Scott K. Lyons, Kent E. Pinkerton, Lloyd C. Trotman, Michael S. Goldberg, Johannes T.-H. Yeh and Mikala Egeblad*

Metal-organic frameworks, NH2-MIL-88(Fe), as carriers for ophthalmic delivery of brimonidine

Se-Na Kim†, Chun Gwon Park†, Beom Kang Huh, Seung Ho Lee, Chang Hee Min, Yun Young Lee, Young Kook Kim, Ki Ho Park and Young Bin Choy*

† These authors contributed equally to this work.

Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases

Chun Gwon Park, Christina A. Hartl, Daniela Schmid, Ellese M. Carmona, Hye-Jung Kim and Michael S. Goldberg*

Implantable small device enabled with magnetic actuation for on-demand and pulsatile drug delivery

Seung Ho Lee, Byung Hwi Kim, Chun Gwon Park, Cheol Lee, Byung Yoon Lim and Young Bin Choy*

Amino-Functionalized Mesoporous Silica Particles for Ocular Delivery of Brimonidine

Se-Na Kim^∇, Song Ah Ko^∇, Chun Gwon Park, Seung Ho Lee, Beom Kang Huh, Yoh Han Park, Young Kook Kim, Ahnul Ha, Ki Ho Park, and Young Bin Choy*

^∇ These authors contributed equally to this work.

Designing Minimally Invasive Preocular Contact Tips for Potential Application in Tear Collection

Seung Ho Lee†, Yong Chan Cho†, Dong Yeon Nam, Beom Kang Huh, Se-Na Kim, Dong Hoon Lee, Chun Gwon Park and Young Bin Choy*

† These authors contributed equally to this work.

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

Daniela Schmid†, Chun Gwon Park†, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Puerto, Yiran Zheng, James Maiarana, Gordon J. Freeman, Kai W. Wucherpfennig, Darrell J. Irvine and Michael S. Goldberg*

† These authors contributed equally to this work.

Nanostructured mucoadhesive microparticles to enhance oral drug bioavailability

Chun Gwon Park, Beom Kang Huh, Se-Na Kim, Seung Ho Lee, Hye Rim Hong and Young Bin Choy*

Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation

Beom Kang Huh¹, Byung Hwi Kim, Se-Na Kim¹, Chun Gwon Park, Seung Ho Lee, Ka Ryeong Kim, Chan Yeong Heo* and Young Bin Choy**

¹ These authors contributed equally to this work.

Application of materials as medical devices with localized drug delivery capabilities for enhanced wound repair

Esther J. Lee¹, Beom Kang Huh¹, Se-Na Kim¹, Jae Yeon Lee, Chun Gwon Park, Antonios G. Mikos* and Young Bin Choy*

¹ These authors contributed equally to this work.

Pattern-Coated Titanium Bone Fixation Plate for Dual Delivery of Vancomycin and Alendronate

Chun Gwon Park‡, Min Park‡, Byung Hwi Kim, Seung Ho Lee, Joong Yull Park, Ho Hyun Park, Kangwon Lee, Hyun-Kwang Seok and Young Bin Choy*

‡ These authors contributed equally to this work.

Implantable batteryless device for on-demand and pulsatile insulin administration

Seung Ho Lee‡, Young Bin Lee‡, Byung Hwi Kim, Cheol Lee, Young Min Cho, Se-Na Kim, Chun Gwon Park, Yong-Chan Cho and Young Bin Choy*

‡ These authors contributed equally to this work.

Enhanced ocular efficacy of topically-delivered dorzolamide with nanostructured mucoadhesive microparticles

Chun Gwon Park, Young Kook Kim, Se-Na Kim, Seung Ho Lee, Beom Kang Huh, Min-A Park, Hyein Won, Ki Ho Park and Young Bin Choy*

Prolonged, acute suppression of cysteinyl leukotriene to reduce capsular contracture around silicone implants

Byung Hwi Kim¹, Min Park¹, Hyo Jin Park, Seung Ho Lee, Sung Yoon Choi, Chun Gwon Park, Su Min Han, Chan Yeong Heo* and Young Bin Choy*

¹ These authors contributed equally to this work.

Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model

Mingyu Lee‡, Chun Gwon Park‡, Beom Kang Huh, Se-Na Kim, Seung Ho Lee, Roza Khalmuratova, Jong-Wan Park, Hyun-Woo Shin and Young Bin Choy*

‡ These authors contributed equally to this work.

Thermosensitive hexanoyl glycol chitosan-based ocular delivery system for glaucoma therapy

Ik Sung Cho†, Chun Gwon Park†, Beom Kang Huh, Myeong Ok Cho, Zehedina Khatun, Zhengzheng Li, Sun-Woong Kang, Young Bin Choy* and Kang Moo Huh*

† These authors contributed equally to this work.

Mathematical modelling of brimonidine absorption via topical delivery of microparticle formulations to the eye

Chun Gwon Park¹, Karam Choi¹, Young Kook Kim, Ki Ho Park, Sungwan Kim* and Young Bin Choy**

¹ These authors contributed equally to this work.

Nanoparticle coating on the silane-modified surface of magnesium for local drug delivery and controlled corrosion

Won Seok Lee, Min Park, Myung Hun Kim, Chun Gwon Park, Beom Kang Huh, Hyun Kwang Seok and Young Bin Choy*

Bioabsorbable Bone Plates Enabled with Local, Sustained Delivery of Alendronate for Bone Regeneration

Woojune Hur¹, Min Park¹, Jae Yeon Lee, Myung Hun Kim, Seung Ho Lee, Chun Gwon Park, Se-Na Kim, Hye Sook Min, Hye Jeong Min, Jin Ho Chai, Sang Jeong Lee, Sukwha Kim, Tae Hyun Choi* and Young Bin Choy*

¹ These authors contributed equally to this work.

Studies on Osmotically Driven Drug Infusion Pump Under the Change in Body-Simulating Environment

Chul Whan Yoon¹, Jae Hong Ahn¹, Doh Park¹, Jae Yeon Lee¹, Chun Gwon Park, Min Park and Young Bin Choy*

¹ These authors contributed equally to this work.

Mucoadhesive microparticles with a nanostructured surface for enhanced bioavailability of glaucoma drug

Chun Gwon Park, Young Kook Kim, Mi Jeung Kim, Min Park, Myung Hun Kim, Seung Ho Lee, Sung Yoon Choi, Won Seok Lee, You Jung Chung, Young Eun Jung, Ki Ho Park* and Young Bin Choy**

Photo-Crosslinkable Chitosan Hydrogel as a Bioadhesive for Esophageal Stents

Chun Gwon Park†, Catherine Shasteen†, Zohreh Amoozgar†, Joonyoung Park, Se-Na Kim, Ji Eun Lee, Min Jae Lee, Yoorock Suh, Hyun Kwang Seok, Yoon Yeo* and Young Bin Choy**

† These authors contributed equally to this work.

Acute suppression of TGF-ß with local, sustained release of tranilast against the formation of fibrous capsules around silicone implants

Subin Park¹, Min Park¹, Byung Hwi Kim¹, Ji Eun Lee, Hyo Jin Park, Seung Ho Lee, Chun Gwon Park, Myung Hun Kim, Ryul Kim, Eun Hee Kim, Chan Yeong Heo, Young Bin Choy*

¹ These authors contributed equally to this work.

Implantable micro-chip for controlled delivery of diclofenac sodium

Seung Ho Lee, Min Park, Chun Gwon Park, Byung-Hwi Kim, Jieun Lee, Sung Yoon Choi, So-rae Nam, Sung-Hye Park, Young Bin Choy*

Bioabsorbable bone fixation plates for X‐ray imaging diagnosis by a radiopaque layer of barium sulfate and poly(lactic‐co‐glycolic acid)

Sung Yoon Choi¹, Woojune Hur¹, Byeung Kyu Kim¹, Catherine Shasteen, Myung Hun Kim, La Mee Choi, Seung Ho Lee, Chun Gwon Park, Min Park, Hye Sook Min, Sukwha Kim, Tae Hyun Choi* and Young Bin Choy*

¹ These authors contributed equally to this work.

Nanostructured mucoadhesive microparticles for enhanced preocular retention

Chun Gwon Park, Mi Jeung Kim, Min Park, Sung Yoon Choi, Seung Ho Lee, Ji Eun Lee, Gyeong-Seon Shin, Ki Ho Park and Young Bin Choy*

Surgical suture assembled with polymeric drug-delivery sheet for sustained, local pain relief

Ji Eun Lee¹, Subin Park¹, Min Park, Myung Hun Kim, Chun Gwon Park, Seung Ho Lee, Sung Yoon Choi, Byung Hwi Kim, Hyo Jin Park Ji-Ho Park, Chan Yeong Heo and Young Bin Choy*

¹ These authors contributed equally to this work.

Polycaprolactone coating with varying thicknesses for controlled corrosion of magnesium

Min Park, Ji Eun Lee, Chun Gwon Park, Seung Ho Lee, Hyun Kwang Seok and Young Bin Choy*

Biodegradable internal fixation plates enabled with X-ray visibility by a radiopaque layer of b-tricalcium phosphate and poly (lactic-co-glycolic acid)

Catherine Shasteen, Seok Min Kwon, Keun Yung Park, Sun Young Jung, Seung Ho Lee, Chun Gwon Park, Myung Hun Kim, Sukwha Kim, Woo-Chan Son, Tae Hyun Choi* and Young Bin Choy*

* Both authors contributed equally to this paper.

Polymeric Tube-Shaped Devices with Controlled Geometry for Programmed Drug Delivery

Min Park, Chun Gwon Park, Seung Ho Lee, Ji Eun Lee, Eunbit Cho, Mark R. Prausnitz and Young Bin Choy*

Linear Delivery of Verapamil via Nanofibrous Sheet-Based System

Ji Eun Lee¹, Chun Gwon Park¹, Byeong Moo An, Myung Hun Kim, Min Park, Seung Ho Lee and Young Bin Choy*

¹ These authors contributed equally to this work.

Microchip for Sustained Drug Delivery by Diffusion Through Microchannels

Seung Ho Lee, Min Park, Chun Gwon Park, Ji Eun Lee, Mark R. Prausnitz and Young Bin Choy*

Polymeric Nanofiber Coated Esophageal Stent for Sustained Delivery of an Anticancer Drug

Chun Gwon Park, Myung Hun Kim, Min Park, Ji Eun Lee, Seung Ho Lee, Jung-Hwan Park, Kyung-Hwan Yoon and Young Bin Choy*

A nanofibrous sheet-based system for linear delivery of nifedipine

Chun Gwon Park, Eunji Kim, Min Park, Jung-Hwan Park and Young Bin Choy*